Study of Prevalence of Martin-Gruber Anomaly in Patients with Carpal Tunnel Syndrome

Keywords

Carpal Tunnel Syndrome; Martin-Gruber Anomaly; Nerve Conduction Velocity.

Introduction

Median-Ulnar connection is the most common peripheral nerve anomaly, with autosomal dominant inheritance, known as Martin- Gruber connection (MGC). Actually, this anomaly is crossover of mainly motor fibers of median nerve to Ulnar in forearm [1, 6, 7], which may produce changes in the innervations of the upper limb muscles, mainly motor part of intrinsic muscles in the hand [2]. Some types of MGC have been recognized. Anastomosis in which the branch anastomotic originates proximally in the median nerve and unites distally in the ulnar nerve is known as Median- Ulnar anastomosis. It can arise between the branches destined to the deep flexor muscle of the fingers, or directly in the median to the ulnar nerve, or between the Anterior Inter-osseous and ulnar nerves or in combinations between these types of anastomoses. However, another type of anastomosis can happen in the forearm. When the anastomotic branch originates proximally in ulnar nerve and unites distally to median nerve is simply called anastomosis of Ulnar-Median type, or Martin-Gruber reverse anastomosis or Marinacci anastomosis.

MGC in almost 10-40% is bilateral, but in the unilateral form, it is commonly seen in right [4, 9].

There is no significant difference between males and females with respect to gender distribution [4, 9].

Also there are very studies about prevalence of Martin-Gruber anomaly, but there are a few studies about prevalence of this anomaly in patients with carpal tunnel syndrome such as Lyer and et al study [13] and Simonetti and et al study [14]. With respect to these studies prevalence of Martin-Gruber anomaly in patients with carpal tunnel syndrome is 1/54% to 26% [10].

In conditions affecting the nerves that supply intrinsic muscles of the hand, this anastomosis can cause confusion in the diagnosis since the crosses of axons can innervate the intrinsic muscles supplied by the ulnar nerve, median nerve or both (KAZAKOS, SMYMIS, XARCHAS et al., 2005). A typical example is Carpal Tunnel Syndrome which symptoms may be incomplete or exacerbate due the existence of these anastomoses, because a modification happens in the upper limb innervation. Moreover, a traumatic injury in forearm nerves might amiss be interpreted as a partial injury of the medium nerve or ulnar nerve (BOLUKBASI, TURGUT and AKYOL, 1999).

Due to high prevalence of Carpal Tunnel syndrome and partially high prevalence of Martin-Gruber anomaly, co morbidity of them can alter the results of evaluations like electro diagnostic tests and plan of treatment of CTS. So, orientation and recognition of MGC may be helpful in treatment of median and ulnar nerves lesions [9].

Purposes of this study are:

1. Prevalence of Martin-Gruber connection in patients with carpal tunnel syndrome
2. Prevalence determination of types of Martin-Gruber connection
3. Determination of gender distribution of martin-Gruber connection in patients with carpal tunnel syndrome.

Materials and Methods

We evaluated presences of Martin-Gruber connection in patients with Carpal Tunnel Syndrome through a prospective analytic-descriptive study, during 13 months study in Neuro-diagnostic ward of Tabriz Imam Reza hospital, Iran. Clinically and para-clinically diagnosed patients with Carpal Tunnel Syndrome were studied for Martin-Gruber connection by electro-diagnostic tests. Then the data were analyzed with respect to age, sex and side of anomaly in patients. All the patients with any disease or condition that may impact on Carpal Tunnel Syndrome, like Hypothyroidism, Uremia, Diabetes, Trauma, any history of Neuropathies, Hypercholesterolemia, Vasculopathies, etc. were excluded from project.

We evaluated all the patients by MEDELEK EMG 4 cannel procedure and measured all the Sensory and Motor Nerve action potentials, Velocities, latencies and late responses of Median and Ulnar Nerves bilaterally with Needle electromyography of muscles in territory of those nerves.

Results

151 patients with documented CTS via EMG_NC were evaluated for Martin-Gruber Connection. We found the electro-neuro-diagnostic evidence of MGC in 19 persons (12.5%) from the all-151 patients with CTS.

From the totally 302 evaluated upper limbs in 151 patients, 285 upper limbs had CTS and from the involved limbs, 25 forearms (8.77%) had MGC.

Mean age in our patients with Martin-Gruber connection was 45.06 +/- 8.43 and in rest of patients in our group was 46.65+/- 11.64;

We found MGC in 14 right forearm and 11 left side. From the all-19 persons with MGC, 4 patients had bilaterally MGC and the rest of them were unilateral. From whom with MGC, 13 persons were female and 6 were male (female: male was more than 2) and the same gender ratio was true about patients CTS in our study group (68.4% females, 31.6% male);

In patients with martin-Gruber connection, 43.8% had Type 1; 87.5% had Type 2 and 37.5% had Type 3 of MGC. It means that some patients (limbs) have had more than one type of MGC.

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Figure A. Schematic drawings of the types of anastomosis found and it’s branch origin, and path of the branch. M: medium nerve. U: nerve to ulnar. AM: anastomosis of Marinacci. AMG: Anastomosis of Martin-Gruber.

Discussion

Carpal tunnel syndrome (CTS) arises from the intermittent or continuous compression or entrapment of the median nerve as it passes through the carpal tunnel from the wrist to the hand. Increased pressure on the median nerve in the carpal tunnel can result in progressive sensory and motor disturbances in parts of the hand innervated by this nerve, leading to pain and loss of function. (Sluiter 2001). Symptoms of CTS include numbness (anesthesia) and tingling (paresthesia) in the anatomic distribution of the median nerve (the area including the thumb, index finger, long finger, and radial half of the ring finger) (Stevens 1999). A nocturnal symptom of sensory disturbance is considered a classic manifestation of carpal tunnel syndrome. Patients frequently complain of pain in the wrist or hand at night or after frequent use of the hands or fingers, commonly relieved by "shaking it out" (Hennessey 1997). Electro-diagnostic studies (EDS) are also used in the diagnosis of carpal tunnel syndrome. Electro-diagnostic studies include electromyography (EMG) and the nerve conduction study (NCS). Due to Electro-diagnostic methods, CTS generally is classified to 3 stages that are summarized in Table below [28].

In the forearm, median and ulnar communication was first described by the Swedish anatomist Martin (in 1763) and later by Gruber (in 1870) and thus referred to as the Martin-Gruber Anastomosis (MGA) [31]. This anastomosis involves axons leaving either the main trunk of median nerve or the anterior inter-osseous nerve, crossing through the forearm to join the main trunk of the ulnar nerve and ultimately innervating the intrinsic hand muscles [31].

In the literature, there are several studies on MGA classification; by different techniques [anatomical [5, 21], histological [20] and electrophysiological [19].

Anatomically there are three types MGC. In Type 1 anastomosis the crossover fibers terminate in the Hypothenar muscles, in the Type 2, in the FDI, and in the Type 3, in the Thenar muscle group. [17]. Due to literature, Type 2 is the most common type [17].

Its reported incidence differs between physiologic and anatomic studies. In the former it has been described as occurring in 5-40% of cases [6, 18, 19] whereas anatomic studies report a narrower range of 10-30.6% [33]. The MGA suggested that unilateral MGA occurs more often in the right side than the left [20]. But no differences were reported with respect to the frequencies of MGA or MGA types for the sexes [17].

In the literature, some researchers cited the clinical importance of MGA [19, 20-23]. The intrinsic muscles of the hand were completely unaffected by median lesions. A lesion of the median nerve situated proximal to the departure of the communicating branch would affect the median Thenar muscles, whereas a lesion below that level would not [3]. Brandsma et al. [23] reported that the clinical importance of this anastomosis is that an isolated ulnar nerve lesion at the elbow may produce an unusual pattern of intrinsic muscle paralysis. The MGA has clinical significance for understanding median nerve lesion and the carpal tunnel syndrome. In addition, Niedenfuhr et al. [24] cited that the intramuscular MGA because the intramuscular course of a nerve is a potential compression site, the cases presented in this study may have an additional clinic implication.

Conclusion

MGC may be source of confusion in diagnosis and management of much neuropathic process in upper limbs like CTS. Normal motor latencies are obtained in such cases. However, there are certain clues to the correct diagnosis: - Median nerve stimulation at the elbow evokes a thenar CMAP with an initial positive deflectin; -A Thenar CMAP with two peaks in the negative phase on stimulation at the elbow; and - An erroneously normal proximal motor latency in the Median nerve with prolongation of distal motor latency results in a spuriously fast conduction velocity by calculation.

Due to partially high incidence of this anastomosis and its role in confusing in some diagnosis of some pathologic process, MGC must be keeping in mind in management of carpal tunnel syndrome to correct diagnosis and select suitable treatment.